I've tried taking mushrooms at several different times of day and the only thing I can tell you is not to take them within three hours or so of waking up. 3 hours being the period of time in the morning when I am surly confused and unpleasent. I at like four grams first thing in the morning with friends who had been up since dawn mantra chanting or whatever you morning people do. Anyway about 2 minutes or so after I took them I started to hear sound as if it were created solely for y benefit like when your falling asleep and tv seems to be talking to you, but I stayed half asleep and confused the whole time, I didn't know where I was or what was going on I just kept watching the waves of sound bounce around the room. I was actually BORED which is friggan amazing but I couldn't pay attention to anything long enough to enjoy it.