The sais shrooms and acid produce cross tolerance:
"Primary effect seems to be the inhibition of neurotransmitter serotonin (5-hydroxytryptamine aka 5-HT), i.e. a 5-HT2A post-synaptic agonist that mimics the effects to 5-HT to put it in jargon. This is the working hypothesis for LSD-25 at the moment and it's probably true for psilocybin as well. These substances also present some cross-tolerance."